ASPIRIN — AGE-REGRESSION.COM

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(WikiLinks: Aspirin) - (Last Revision: 6/11/2022)

Aspirin (acetylsalicylic acid, ASA) is one of the top-prescribed medications worldwide. This agent made a historical entry from being originally developed as analgesic and antipyretic drug; nowadays is predominantly used for primary and secondary cardiovascular prevention. Yet, many of its complementary effects regarding agerelated diseases are still to be unveiled (Desborough and Keeling 2017). Aspirin might be one of the most appropriate agents to be appointed as a promising antiaging drug due to low costs and simplicity of treatment and well-investigated multifaceted properties regarding cardiovascular disease (CVD) and cancer. [1]

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Aspirin:

One of the most common causes of disability and death can arisefrom blood clots that develop inside a vessel. When dislodged,they may cause heart attack, or stroke. Aspirin (acetylsalicylic acid)(11) is an analgesic, antiinflammatory and antipyretic drug. It actsthrough inhibition of cyclooxygenase, the enzyme responsible forsynthesis of prostaglandins and thromboxanes from arachidonic acid. Aspirin inhibits platelet aggregation and has an immediateand long-lasting effect on blood platelets, making them less likelyto clump, hence reducing the risk of further clots. It is reported that aspirin delays the onset of endothelial senescence by preventing reduction of NO formation/generation and has also been found to inhibit senescence-associated b-galactosidase activity and increased telomerase activity [33,34].

[2009] Synthetic drugs with anti-ageingeffects

33 Grosser, N. and Schroder, H. (2003) Aspirin protects endothelial cells from oxidantdamage via nitric oxide-cGMP pathway. Arterioscler. Thromb. Vasc. Biol. 23, 1345–1351

34 Vasa, M. et al. (2000) Nitric oxide activates telomerase and delays endothelial cellsenescence. Circ. Res. 87, 540–542