DEPRENYL / SELEGILINE

(WikiLink: Deprenyl) - (Last Revision: 5/24/2022)

⫸ (−)Deprenyl (35) is an inhibitor of monoamine oxidase B (MAO B). It is known to up-regulate the activity of antioxidant enzymes SOD and CAT in the dopaminergic region of the brain. The drug is also the only chemical that has been repeatedly found to extend the lifespan of rats, mice, hamsters and dogs in animal models. In addition, the drug can also enhance antioxidant enzyme activity in tissues outside the brain, such as the adrenal glands, heart, kidneys, and spleen. The results showed that deprenyl can activate a variety of humoral factors (interferon-γ, tumor necrosis factor-α, interleukin-1β, 2, 6, etc.) and enhance the function of natural killer cells. These new observations of (−)deprenyl up-regulating SOD and CAT activities in the brain and in extra-brain vital organs involve anti-tumorigenic and immunomodulatory effects, it may be better explained by reports of significantly longer lifespan in experimental animals in the past. These combined drug effects may cause homeo- stasis regulation of the body’s neuro-immune-endocrine axis for protection against aging [154]. ⫷[1]

🔷 ? 🔷

4.3 (−)Deprenyl
⫸(−)Deprenyl (35) is an inhibitor of monoamine oxidase B (MAO B). It is known to up-regulate the activity of antioxidant enzymes SOD and CAT in the dopaminer- gic region of the brain. The drug is also the only chemi- cal that has been repeatedly found to extend the lifespan of rats, mice, hamsters and dogs in animal models. In addition, the drug can also enhance antioxidant enzyme activity in tissues outside the brain, such as the adrenal glands, heart, kidneys, and spleen. The results showed that deprenyl can activate a variety of humoral factors (interferon-γ, tumor necrosis factor-α, interleukin-1β, 2, 6, etc.) and enhance the function of natural killer cells. These new observations of (−)deprenyl up-regulating SOD and CAT activities in the brain and in extra-brain vital organs involve anti-tumorigenic and immunomod- ulatory effects, it may be better explained by reports of significantly longer lifespan in experimental animals in the past. These combined drug effects may cause homeo- stasis regulation of the body’s neuro-immune-endocrine axis for protection against aging [154].⫷ [1]